Questions on Revised Cramer Rules for a bicyclo-diester compound

• The question 1 (Normal constituent of the body) relies on predefined lookup list, so if this particular structure is not in the list, the answer will be "No".

Returns true if the query is isomorphic to one of the structures loaded from a preconfigured file of a type SDF, SMI, CSV
Is the substance a normal constituent of the body, or an optical isomer of such?This question throws into class I all normal constituents of body tissues and fluids, including normal metabolites. Hormones are excluded, as are, by implication, the metabolites of environmental and food contaminants or those resulting from disease state.
Note the answer of the question relies on an incomplete list of compounds, identified by an expert as a normal body constituents.If you believe a query compound is wrongly identfied as a such, or not recognised, please consult and/or update the list. {depends on your installation}\bodymol.inchi

• The hydrolysis rules are described in the manual https://sourceforge.net/projects/toxtree/files/toxtree/Toxtree_user_manual.pdf/download

• The question 22 (Common component of the food) also relies on a predefined lookup list, same reasoning a for Q1

Q22 Returns true if the query is isomorphic to one of the structures loaded from a preconfigured file of a type SDF, SMI, CSV Is the substance a common component of food (C) or stucturally closed related to a common component of food?
(C) Common component of food. In something as diverse , changing and occasionally uncertain as natural occurence, it is only possible to define a guideline, not a firm rule. For a decision tree, the term common component of food denotes a substance that has been reported in the recognised literature as occuring in significant quantity (approximately 50 ppm or more) in at least one major food, or in trace quantities at the ppm level or less in several foods, including minor or less frequently consumed foods. The latter include spices, herbs and ethnic specialities.This definition excludes natural or man made contaminants and hormones.
Note the answer of the question relies on an incomplete list of compounds, identified by an expert as a common component of food.If you believe a query compound is wrongly identfied as a such, or not recognised, please consult and/or update the list. {depends on your installation}\foodmol.inchi

The tree and the rules can also be inspected via the Method/View decision tree menu

The lookup lists location can be found using the Help/Files info menu.

Thank you for the response. I will refer to the manual and other references.

I was using the Revised Cramer rules so Q22 is about the number of carbons in the rings of the structure. For the query structure above, the Toxtree answer appears to be incorrect. It answered "No" when there are many more ring carbons than 12.