I own a small domain for use at home and my ISP provides me with a <anything>@<yoursubdomain>.isp type account. I'm swamped with randomly generated addresses that don't correspond with anything I've ever given out and I'd like (ideally) deleted at source rather than downloaded to my PC. I've recently installed GFI ME at work which has a "directory harvesting" module which marks as spam everything that is addressed to a non-existent recipient within the domain. For SpamPal, a module in which you could list all your alternate valid email addresses, and that would block anything not sent to one of those addresses, would be a great first level of filtering.
Ideally I'd like SpamPal to be able to delete some messages directly where it has a very high confidence that it has detected Spam. An alternative approach would be to introduce Spam Confidence Levels so that we could use mail client rules to sort some spam out for routine manual checking while letting more obvious spam be moved to a generally ignored spam sink.
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Up to now SpamPal is a proxy only which cannot delete mails. I think that at least the IMAP4 proxy includes a feature (check, tag and upload mail to IMAP4 spam-trap) which should make it quite easy to add a delete function.
The Spam Confidence Level feature has already been mentioned as request. Our approach could be to give a certain score and weighting to all plugins, wls and bls and mark a message as spam if the cumulated score is over a threshold. All of that should be user configurable.
In this particular case I suggest disabling the catch-all feature and only get mails for existing accounts. I had to take the same step after I had received thousands of spam mails per day to non-existing email addresses within my various domains.