...Blizzard has stayed silent over this matter and refused to address the freezing issues. This work-a-round be it a partial one will prevent you from having to use ctrl-alt-del and logging off your system.
It uses a simple hot hey combination of holding down the following keys ctrl-alt-b
This will simply kill the hung exe that is consuming literally gigs of memory. the exe that I see is :
Diablo III64.exe and Diablo III.exe
The application silently runs in the background and waits for the combination of keys to be held down and will kill said application above. ...